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# Biomedical engineering semester 3 syllabus 2018

Biomedical Engineering Semester 3 Syllabus 2018 – The syllabus for Biomedical Engineering for Mumbai University for Semester 3 is of 2018 and has a credit based system of marking.There is a common subject of Applied Mathematics 3 for all branches.Other subjects of this semester include Basics of Human Physiology, Electric Analysis and Synthesis and Electronic circuit analysis and design.

## Applied Mathematics III

1 Laplace Transform
1.1 Laplace Transform (LT) of Standard Functions: Definition of
Laplace transform, Condition of Existence of Laplace transform,
Laplace transform of , ( ),cos( ), at e Sin at at sinh( ),cosh( ), n at at t
Heaviside unit step function, Dirac-delta function, Laplace transform of
Periodic function

1.2 Properties of Laplace Transform: Linearity, first shifting theorem,second shifting theorem, multiplication by n
t ,Division by t, Laplace Transform of derivatives and integrals, change of scale, convolution
theorem, Evaluation of integrals using Laplace transform.
2 Inverse Laplace Transform & its Applications

2.1
Partial fraction method, Method of convolution, Laplace inverse by
derivative
6
2.2 Applications of Laplace Transform: Solution of ordinary differential
equations, Solving RLC circuit differential equation of first order and
second order with boundary condition using Laplace transform (framing
of differential equation is not included)
3 Fourier Series
3.1 Introduction: Orthogonal and orthonormal set
of functions, Introduction of Dirichlet’s conditions, Euler’s formulae
11
3.2 Fourier Series of Functions: Exponential, trigonometric functions of any
period =2L, even and odd functions, half range sine and cosine series
3.3 Complex form of Fourier series, Fourier integral representation, Fourier
Transform and Inverse Fourier transform of constant and exponential
function.
4 Vector Algebra & Vector Differentiation
4.1 Review of Scalar and Vector Product: Scalar and vector product of three
and four vectors,
Vector differentiation, Gradient of scalar point function, Divergence and
Curl of vector point function
7
4.2 Properties: Solenoidal and irrotational vector fields, conservative vector
field
5 Vector Integral
5.1 Line integral 6
5.2 Green’s theorem in a plane, Gauss’ divergence theorem and Stokes’
theorem
6 Complex Variable & Bessel Functions
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University of Mumbai, Biomedical Engineering, Rev 2016-17
6.1 Analytic Function: Necessary and sufficient conditions (No Proof),
Cauchy Reiman equation Cartesian form (No Proof) Cauchy Reiman
Equation in polar form (with Proof), Milne Thomson Method and it
application, Harmonic function, orthogonal trajectories
11
6.2 Mapping: Conformal mapping, Bilinear transformations, cross ratio, fixed
points
6.3 Bessel Functions: Bessel’s differential equation, Properties of Bessel
function of order +1/2 and
-1/2, Generating function, expression of
cos(xsin? ), sin (x sin? ) in term of Bessel functions

Assessment:
Internal Assessment consists of two tests out of which; one should be compulsory class test (on
minimum 02 Modules) and the other is either a class test or assignment on live problems or course
project.
Books Recommended:
Text Books:
1. H.K. Das, “Advanced engineering mathematics”, S . Chand, 2008
2. A. Datta, “Mathematical Methods in Science and Engineering”, 2012
3. B.S. Grewal, “Higher Engineering Mathematics”, Khanna Publication

Reference Books:
1. B. V. Ramana, “Higher Engineering Mathematics”, Tata Mc-Graw Hill Publication
2. Wylie and Barret, “Advanced Engineering Mathematics”, Tata Mc-Graw Hill 6th Edition
3. Erwin Kreysizg, “Advanced Engineering Mathematics”, John Wiley & Sons, Inc
4. Murry R. Spieget, “Vector Analysis”, Schaum’s outline series, Mc-Graw Hill Publication
Theory Examination:
1. Question paper will comprise of total 06 questions, each carrying 20 marks.
2. Total 04 questions need to be solved.
3. Question No: 01 will be compulsory and based on entire syllabus wherein sub-questions of 5
4. Remaining questions will be randomly selected from all the modules.

## Basics of Human Physiology (BHP)

1 Organization of Human Body:
Cell, Tissue, Organ, Organ system, Structure and functions of cell, Polarization and
Depolarization of Cell, Types of tissues, Homeostasis, Positive and Negative
Feedback Mechanism
Muscle Physiology: Muscle physiology and aspects of Skin Resistance
05
2 Cardiovascular System: Anatomy of Cardiovascular System, Heart, Conductive
Tissues of Heart, Cardiac Cycle, Heart Valves, Systemic
and Pulmonary Circulation, Transmission of Cardiac Impulse,
Blood Pressure, ECG, Einthoven’s Triangle, Twelve Lead System and
ECG Waveforms
Respiratory System: Anatomy of Respiratory System, Ventilation, Exchange in
gases in the alveoli, Spirometer (Forced Expiratory Volumes)
12
3 Blood: Composition of Blood – Blood cells and their functions, Haemoglobin, Blood
Grouping, Coagulation, Wound Healing.
05
4 Alimentary System: All organs of the Digestive System, other secretions and main
Functions, Deglutition and Defecation.
Urinary System: Structure of Nephron, Function of Kidney, Urinary Bladder,
Urethra, Internal/External Sphincters, Formation of Urine, Micturition
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5 Nervous System: Different parts, their functions. Reflex actions and reflex are,
Function of Sympathetic and Parasympathetic nervous system. Nerve conduction
and action potentials.
Special Senses:
Eyes-Structure, Refractive Medias of the Eye, Formation of Image on the Retina.
Ear – Structure of Cochlea, Hearing mechanism
10
6 Reproductive System: (Male and Female) Different Organs and their functions.
Main actions of Androgens, Oestrogens and Progesterone.
Endocrine System: All glands, their Secretions and functions. Control of secretions.

Assessment:

University of Mumbai, Biomedical Engineering, Rev 2016-17
Internal Assessment consists of two tests out of which; one should be compulsory class test (on
minimum 02 Modules) and the other is either a class test or assignment on live problems or course
project.

Books Recommended:
Text books:
1. Anatomy and Physiology in Health and Illness: Ross and Wilson. ( ELBS Pub )
2. Essentials of Anatomy and Physiology: Elaine N Marieb. (Pearson Education)
Reference Books:
1. Physiology of Human Body. : Guyton. ( Prism Book )
2. Review of Medical Physiology: William Ganong. ( Prentice Hall Int )
3. Principles of Anatomy and Physiology: Tortora and Grabowski. ( Harper collin Pub)
4. Anatomy and Physiology: Elaine N Marieb. (Pearson Education)
Theory Examination:
1. Question paper will comprise of 6 questions, each carrying 20 marks.
2. Total four questions need to be solved.
3. Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be
4. Remaining question will be randomly selected from all the modules.

## Electrical Network Analysis and Synthesis (ENAS)

1 Introduction:
Review of D.C. & A.C. circuits,
DC Circuits: Current & Voltage Source Transformation, Source Shifting
Mesh & Node Analysis:
Mesh & Node Analysis of D.C. & A.C. circuits with independent & dependent sources.
(Introduction to coupled circuits).
07
2 Network Theorems ( D.C. & A.C. circuits):
Superposition, Thevenin’s & Norton’s Theorem (with independent and dependent
sources), Maximum power transfer theorem.
06
3 Circuit Analysis:
Introduction to Graph Theory. Tree, link currents, branch voltages, cut set & tie set,
Mesh & Node Analysis, Duality.
06
4 Time and Frequency Response of Circuits:
First & second order Differential equations, initial conditions. Evaluation & Analysis of
Transient Steady state responses using Classical Technique as well as by Laplace
Transform (for simple circuits only). Transfer function, Concept of poles and zeros.

09
5 Two-Port Networks:
Concept of two-port network. Driving point and Transfer Functions, Open Circuit
impedance (Z) parameters, Short Circuit admittance (Y) parameters, Transmission
(ABCD) parameters. Inverse Transmission (A’B’C’D’) parameters. Hybrid (h)
parameters. Inter Relationship of different parameters. Interconnections of two-port
networks. Terminated two-port networks.
10
6 Fundamentals of Network Synthesis:
Positive real functions, Driving Point functions, Properties of positive real functions.
Testing Positive real functions. Testing driving point functions, Maximum modulus
theorem, Properties of Hurwitz polynomials, Residue computations, Even & odd
functions, Driving Point Synthesis with L-C, R-C, R-L and R-L-C networks.
10
Assessment:
Internal Assessment consists of two tests out of which; one should be compulsory class test (on
minimum 02 Modules) and the other is either a class test or assignment on live problems or course
project.
Books Recommended:
Text Books:
1. Sudhakar & S.P. Shyammohan, Circuits and Networks, Tata McGraw Hill, thirteenth reprint,
2000.
2. William H. Hayt, Jack e. Kemmerly & Steven M. Durbin, Engineering Circuit Analysis,
McGraw Hill International, sixth edition, 2202.
3. Raymond A. DeCarlo & Pen-Min Lin, Linear Circuit Analysis, Oxford University Press,
second edition, 2001.
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4. M. E. Van Valkenburg, Introduction to Modern Network Synthesis, Wiley Eastern Ltd.

Reference Books:
1. Artice M. Davis, Linear Circuit Analysis, Thomson Asia Pte. Ltd, Singapore, first edition,
2001.
2. M.E. Van Valkenburg, Network Analysis, Prentice Hall of India, third edition
3. C.L.Wadhwa, Network Analysis and Synthesis, New Age International Publisher, Third
Edition.
Theory Examination:
1. Question paper will comprise of 6 questions, each carrying 20 marks.
2. Total four questions need to be solved.
3: Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be
4: Remaining question will be randomly selected from all the modules.

## Electronic Circuit Analysis and Design (ECAD)

1. Diodes Circuits:
Basics of PN junction diode – Equation, characteristics.
Clipper and Clamper Circuits using diodes, Zener Diode – Characteristics and Working,
Study Zener as a voltage regulator
05
2. Bipolar Junction Transistor:
Working of PNP and NPN Transistor. Configurations (CB, CC, CE), comparison, Q-Point,
DC load line. BJT Biasing – DC analysis, Stability. (Fixed, Self, Voltage divider, Collector
to base, Collector to base self). BJT as a switch.
10
3. .A.C. Equivalent Model – re model, h-parameter model (Exact and Approximate),
Hybrid-? model
A.C. Analysis-(Using any one model): A.C. load line, A.C. analysis of CE, CB, CC
amplifier configurations, Effects of RS and RL, Comparison between various amplifiers.
Low frequency and High frequency analysis, Frequency response of Single stage
amplifier. Design of single stage amplifier using BJT.
10
4. Junction Field Effect Transistor:
Working and basic terminology related to JFET. Configurations (CS, CG, CD),
comparison, Q-Point, DC load line. JFET Biasing – Fixed, Self, Voltage divider, Concept
of stability against device parameters and temperature, zero temperature drift. A.C.
Equivalent model of JFET.
A.C. Analysis of amplifiers using CS, CG and CD amplifier configurations, Effects of RS
and RL, Comparison between various amplifiers.
Low frequency and High frequency analysis, Frequency response of Single stage
amplifier. Design of single stage amplifier using JFET.
12
5. MOSFET:
Working of Depletion and Enhancement type MOSFET Construction, Characteristics and
equations, Basic MOSFET Applications
04
6. Multistage Amplifiers:
Cascode – DC and AC analysis, characteristics
Darlington amplifier- DC and AC analysis, characteristics

Assessment:
Internal Assessment consists of two tests out of which; one should be compulsory class test (on
minimum 02 Modules) and the other is either a class test or assignment on live problems or course
project.

Books Recommended:
Text Books:
1. Neamen Donald A., Electronics Ckt. Analyzer & Design, 2nd ed., Tata McGraw Hill.
2. Boylestad Robert L., Nashelsky Louis, Electronics Devices & Circuits, Pearson Education.
3. Semiconductor Data Manual, BPB Publications.
Reference Books:
1.Malvino—Electronic Principles , 6/e ,TMH
2. Millman & Halkias: Basic Electronic Principles; TMH.
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University of Mumbai, Biomedical Engineering, Rev 2016-17
3..Martin Roden, Gordon carpenter, William Wieseman, Electronic design, Fourth edtion,
Sroff publishers.
4. Donald Schilling & Charles Belove, Electronic Circuits Discrete and Integrated, Third
edition, Mcgraw Hill.
Theory Examination:
1. Question paper will comprise of 6 questions, each carrying 20 marks.
2. Total four questions need to be solved.
3: Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be
4: Remaining question will be randomly selected from all the modules.

## Biomaterials Prosthetics and Orthotics (BPO)

1 Introduction: Introduction of Biomaterials, Classification
of Biomaterials, General Applications.
Techniques for characterization of Surface properties of Biomaterials: Electron
Spectroscopy for Chemical Analysis (ESCA), Secondary Ion Mass
Spectrometry(SIMS), Infrared Spectroscopy, Contact Angle Method.
08
2 Properties and Applications of Polymeric and degradable Biomaterials:
Classification, polyurethanes, PTFE, Polyethylene, Polypropylene, Polyacrylates,
PMMA, PHEMA, Hydrogel, Silicone rubber, Biopolymer in fabrication of biodevices
and implants, Thermoplastic and thermosetting plastics.
Degradable biomaterials ( PGA and PLA), applications in
drug delivery systems.
Composite Biomaterials: Properties, classification
and Applications of Composite Biomaterials in fabrication
of biodevices and implants.
Applications of biomaterials in Drug delivery systems,
09
3 Properties and Applications of Metallic Biomaterials and its Biocompatibility:
Stainless steel, Titanium, Titanium based alloys, Cobalt – Chromium alloys in
fabrication of bio-devices and implants.
Properties and Applications of Ceramic Biomaterials: Classification, Alumina,
Zirconia and types, Bioglass, Calcium Phosphate, Tricalcium phosphate in fabrication of
biodevices and implants.
08
4 Biological Testing of Biomaterials: Physiochemical Test, Mechanical Test, Invitro and
Invivo types, Different forms of corrosion, Wear, Electrochemical Corrosion Testing.
08
5 Movement biomechanics
Overview of joints and movments, anatomical levers, gait cycle ( stance and swing
phase with stick diagram), gait parameters
05
6 Prosthetics and Orthotics
Principles of three point pressure,
Lower limb prostheses, partial weight bearing-PTB socket, total contact- quadrilateral
socket.
Upper limb prosthesis ( terminal devices)
Spinal orthoses.

Assessment:
Internal Assessment consists of two tests out of which; one should be compulsory class test (on
minimum 02 Modules) and the other is either a class test or assignment on live problems or course
project.

Books Recommended:
Text Books:
1. Biomaterial Science and Engineering: J.V. Park (Plenum Press- New York)
2. Fundaments of Biomedical Engineering: G S. Sawhney (New Age International Publication)
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University of Mumbai, Biomedical Engineering, Rev 2016-17
3. Biomaterial Science: An Introduction to Materials in Medicine, Ratner & Hoffmann
4. American Atlas of Orthopedics: Prosthetics, C. V. Mosby.
5. American Atlas of Orthopedics: Orthotics, C. V. Mosby
6. Basics of Biomechanics by Ajay Bahl, Jaypee publications.
Reference Books:
1. Encyclopedia of Medical Devices and Instrumentation: John G. Webster. Vol. I, II, III, IV (Marcel
Dekkar Pub).
2. Encyclopedia – Handbook of Biomaterials and Bioengineering: Part-A: Materials Vol I, II (Marcel
Dekkar Pub) Part – B: Applications Vol. I, II.
3. Design Engineering on Biomaterials for medical devices: David Hill, John Willey Publication
4. Biological Performance of Materials, 2nd Edition – Jonathan Black, Marcel Dekker Inc. New York.
Basel. Hong Kong
Theory Examination:
1. Question paper will comprise of 6 questions, each carrying 20 marks.
2. Total four questions need to be solved.
3. Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be
4. Remaining question will be randomly selected from all the modules.

## Object Oriented Programming

1 Introduction to Object
Oriented Programming
1.1OO Concepts: Object, Class, Encapsulation, Abstraction,
Inheritance, Polymorphism.
1.2Features of Java, JVM
1.3 Basic Constructs/Notions: Constants, variables and data
types, Operators and Expressions,Revision of Branching
and looping
02
2 Classes, Object
and Packages
2.1Class,Object, Method.
2.2 Constructor, Static members and methods
2.3 Passing and returning Objects
2.5 Packages in java, creating user defined packages, access
specifiers.
05
3 Array, String
and Vector
3.1 Arrays, Strings, StringBuffer
3.2 Wrapper classes, Vector
04
4 Inheritance
and Interface
4.1Types of Inheritance, super keyword, Method Overriding,
abstract class and abstract method, final keyword,
4.2 Implementing interfaces, extending interfaces
03
5 Exception
Handling and
g
5.1 Error vs Exception, try, catch, finally, throw, throws,
creating own exception
Synchronization
04
6 GUI
programming
in JAVA
6.1 Applet: Applet life cycle, Creating applets, Graphics class
methods, Font and Color class, parameter passing.
6.2 Event Handling: Event classes and event listener
6.3 Introduction to AWT: Working with windows, Using
AWT controls- push Buttons, Label, Text Fields, Text
Area, Check Box, and Radio Buttons.
06
Note: #Out of four hours of practical two hours to be conducted as theory

List of Laboratory Experiments: (Any Fifteen experiments and three assignments)
1. Program on various ways to accept data through keyboard and unsigned right shift operator.
2. Program on branching, looping, labelled break and labelled continue.
3. Program to create class with members and methods, accept and display details for single object.
6. Program on passing object as argument and returning object
7. Program on creating user defined package

University of Mumbai, Biomedical Engineering, Rev 2016-17
8. Program on 1D array
9. Program on 2D array
10. Program on String
11. Program on StringBuffer
12. Program on Vector
13. Program on single and multilevel inheritance (Use super keyword)
14. Program on abstract class
15. Program on interface demonstrating concept of multiple inheritance
16. Program on dynamic method dispatch using base class and interface reference.
17. Program to demonstrate try, catch, throw, throws and finally.
18. Program to demonstrate user defined exception
20. Program on concept of synchronization
21. Program on Applet to demonstrate Graphics, Font and Color class.
22. Program on passing parameters to applets
23. Program to create GUI application without event handling using AWT controls
24. Program to create GUI application with event handling using AWT controls
Assessment:
Term Work:
Term work shall consist of minimum 15 experiments and 3 Assignments
The distribution of marks for term work shall be as follows:
Laboratory work (Experiments): 20 Marks
Laboratory work (journal) : 10 Marks
Assignments : 15 Marks
Attendance : 5 Marks
The final certification and acceptance of term work ensures the satisfactory performance of laboratory
work and minimum passing in the term work.

Books Recommended:
Text books:
1. Herbert Schildt, ‘JAVA: The Complete Reference’, Ninth Edition, Oracle Press.
2. Sachin Malhotra and Saurabh Chaudhary, “Programming in Java”, Oxford University
Reference Books:
1. Ivor Horton, ‘Beginning JAVA’, Wiley India.
2. DietalandDietal, ‘Java: How to Program’, 8/e,PHI
3. ‘JAVA Programming’, Black Book, Dreamtech Press.
Practical and oral examination will be based on suggested practical list and entire syllabus.
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University of Mumbai, Biomedical Engineering, Rev 2016-17
Course