**Biomedical Engineering Semester 3 Syllabus 2018** – The syllabus for Biomedical Engineering for Mumbai University for Semester 3 is of 2018 and has a credit based system of marking.There is a common subject of Applied Mathematics 3 for all branches.Other subjects of this semester include Basics of Human Physiology, Electric Analysis and Synthesis and Electronic circuit analysis and design.

## Biomedical Engineering Semester 3 Syllabus 2018

## Applied Mathematics III

1 Laplace Transform

1.1 Laplace Transform (LT) of Standard Functions: Definition of

Laplace transform, Condition of Existence of Laplace transform,

Laplace transform of , ( ),cos( ), at e Sin at at sinh( ),cosh( ), n at at t

Heaviside unit step function, Dirac-delta function, Laplace transform of

Periodic function

1.2 Properties of Laplace Transform: Linearity, first shifting theorem,second shifting theorem, multiplication by n

t ,Division by t, Laplace Transform of derivatives and integrals, change of scale, convolution

theorem, Evaluation of integrals using Laplace transform.

2 Inverse Laplace Transform & its Applications

2.1

Partial fraction method, Method of convolution, Laplace inverse by

derivative

6

2.2 Applications of Laplace Transform: Solution of ordinary differential

equations, Solving RLC circuit differential equation of first order and

second order with boundary condition using Laplace transform (framing

of differential equation is not included)

3 Fourier Series

3.1 Introduction: Orthogonal and orthonormal set

of functions, Introduction of Dirichlet’s conditions, Euler’s formulae

11

3.2 Fourier Series of Functions: Exponential, trigonometric functions of any

period =2L, even and odd functions, half range sine and cosine series

3.3 Complex form of Fourier series, Fourier integral representation, Fourier

Transform and Inverse Fourier transform of constant and exponential

function.

4 Vector Algebra & Vector Differentiation

4.1 Review of Scalar and Vector Product: Scalar and vector product of three

and four vectors,

Vector differentiation, Gradient of scalar point function, Divergence and

Curl of vector point function

7

4.2 Properties: Solenoidal and irrotational vector fields, conservative vector

field

5 Vector Integral

5.1 Line integral 6

5.2 Green’s theorem in a plane, Gauss’ divergence theorem and Stokes’

theorem

6 Complex Variable & Bessel Functions

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6.1 Analytic Function: Necessary and sufficient conditions (No Proof),

Cauchy Reiman equation Cartesian form (No Proof) Cauchy Reiman

Equation in polar form (with Proof), Milne Thomson Method and it

application, Harmonic function, orthogonal trajectories

11

6.2 Mapping: Conformal mapping, Bilinear transformations, cross ratio, fixed

points

6.3 Bessel Functions: Bessel’s differential equation, Properties of Bessel

function of order +1/2 and

-1/2, Generating function, expression of

cos(xsin? ), sin (x sin? ) in term of Bessel functions

**Assessment**:

Internal Assessment consists of two tests out of which; one should be compulsory class test (on

minimum 02 Modules) and the other is either a class test or assignment on live problems or course

project.

Books Recommended:

Text Books:

1. H.K. Das, “Advanced engineering mathematics”, S . Chand, 2008

2. A. Datta, “Mathematical Methods in Science and Engineering”, 2012

3. B.S. Grewal, “Higher Engineering Mathematics”, Khanna Publication

**Reference Books:**

1. B. V. Ramana, “Higher Engineering Mathematics”, Tata Mc-Graw Hill Publication

2. Wylie and Barret, “Advanced Engineering Mathematics”, Tata Mc-Graw Hill 6th Edition

3. Erwin Kreysizg, “Advanced Engineering Mathematics”, John Wiley & Sons, Inc

4. Murry R. Spieget, “Vector Analysis”, Schaum’s outline series, Mc-Graw Hill Publication

Theory Examination:

1. Question paper will comprise of total 06 questions, each carrying 20 marks.

2. Total 04 questions need to be solved.

3. Question No: 01 will be compulsory and based on entire syllabus wherein sub-questions of 5

marks will be asked.

4. Remaining questions will be randomly selected from all the modules.

## Basics of Human Physiology (BHP)

1 Organization of Human Body:

Cell, Tissue, Organ, Organ system, Structure and functions of cell, Polarization and

Depolarization of Cell, Types of tissues, Homeostasis, Positive and Negative

Feedback Mechanism

Muscle Physiology: Muscle physiology and aspects of Skin Resistance

05

2 Cardiovascular System: Anatomy of Cardiovascular System, Heart, Conductive

Tissues of Heart, Cardiac Cycle, Heart Valves, Systemic

and Pulmonary Circulation, Transmission of Cardiac Impulse,

Blood Pressure, ECG, Einthoven’s Triangle, Twelve Lead System and

ECG Waveforms

Respiratory System: Anatomy of Respiratory System, Ventilation, Exchange in

gases in the alveoli, Spirometer (Forced Expiratory Volumes)

12

3 Blood: Composition of Blood – Blood cells and their functions, Haemoglobin, Blood

Grouping, Coagulation, Wound Healing.

05

4 Alimentary System: All organs of the Digestive System, other secretions and main

Functions, Deglutition and Defecation.

Urinary System: Structure of Nephron, Function of Kidney, Urinary Bladder,

Urethra, Internal/External Sphincters, Formation of Urine, Micturition

08

5 Nervous System: Different parts, their functions. Reflex actions and reflex are,

Function of Sympathetic and Parasympathetic nervous system. Nerve conduction

and action potentials.

Special Senses:

Eyes-Structure, Refractive Medias of the Eye, Formation of Image on the Retina.

Ear – Structure of Cochlea, Hearing mechanism

10

6 Reproductive System: (Male and Female) Different Organs and their functions.

Main actions of Androgens, Oestrogens and Progesterone.

Endocrine System: All glands, their Secretions and functions. Control of secretions.

**Assessment**:

University of Mumbai, Biomedical Engineering, Rev 2016-17

Internal Assessment consists of two tests out of which; one should be compulsory class test (on

minimum 02 Modules) and the other is either a class test or assignment on live problems or course

project.

**Books Recommended:**

Text books:

1. Anatomy and Physiology in Health and Illness: Ross and Wilson. ( ELBS Pub )

2. Essentials of Anatomy and Physiology: Elaine N Marieb. (Pearson Education)

Reference Books:

1. Physiology of Human Body. : Guyton. ( Prism Book )

2. Review of Medical Physiology: William Ganong. ( Prentice Hall Int )

3. Principles of Anatomy and Physiology: Tortora and Grabowski. ( Harper collin Pub)

4. Anatomy and Physiology: Elaine N Marieb. (Pearson Education)

Theory Examination:

1. Question paper will comprise of 6 questions, each carrying 20 marks.

2. Total four questions need to be solved.

3. Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be

asked.

4. Remaining question will be randomly selected from all the modules.

## Electrical Network Analysis and Synthesis

(ENAS)

1 Introduction:

Review of D.C. & A.C. circuits,

DC Circuits: Current & Voltage Source Transformation, Source Shifting

Mesh & Node Analysis:

Mesh & Node Analysis of D.C. & A.C. circuits with independent & dependent sources.

(Introduction to coupled circuits).

07

2 Network Theorems ( D.C. & A.C. circuits):

Superposition, Thevenin’s & Norton’s Theorem (with independent and dependent

sources), Maximum power transfer theorem.

06

3 Circuit Analysis:

Introduction to Graph Theory. Tree, link currents, branch voltages, cut set & tie set,

Mesh & Node Analysis, Duality.

06

4 Time and Frequency Response of Circuits:

First & second order Differential equations, initial conditions. Evaluation & Analysis of

Transient Steady state responses using Classical Technique as well as by Laplace

Transform (for simple circuits only). Transfer function, Concept of poles and zeros.

09

5 Two-Port Networks:

Concept of two-port network. Driving point and Transfer Functions, Open Circuit

impedance (Z) parameters, Short Circuit admittance (Y) parameters, Transmission

(ABCD) parameters. Inverse Transmission (A’B’C’D’) parameters. Hybrid (h)

parameters. Inter Relationship of different parameters. Interconnections of two-port

networks. Terminated two-port networks.

10

6 Fundamentals of Network Synthesis:

Positive real functions, Driving Point functions, Properties of positive real functions.

Testing Positive real functions. Testing driving point functions, Maximum modulus

theorem, Properties of Hurwitz polynomials, Residue computations, Even & odd

functions, Driving Point Synthesis with L-C, R-C, R-L and R-L-C networks.

10

Assessment:

Internal Assessment consists of two tests out of which; one should be compulsory class test (on

minimum 02 Modules) and the other is either a class test or assignment on live problems or course

project.

Books Recommended:

Text Books:

1. Sudhakar & S.P. Shyammohan, Circuits and Networks, Tata McGraw Hill, thirteenth reprint,

2000.

2. William H. Hayt, Jack e. Kemmerly & Steven M. Durbin, Engineering Circuit Analysis,

McGraw Hill International, sixth edition, 2202.

3. Raymond A. DeCarlo & Pen-Min Lin, Linear Circuit Analysis, Oxford University Press,

second edition, 2001.

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4. M. E. Van Valkenburg, Introduction to Modern Network Synthesis, Wiley Eastern Ltd.

**Reference Books:**

1. Artice M. Davis, Linear Circuit Analysis, Thomson Asia Pte. Ltd, Singapore, first edition,

2001.

2. M.E. Van Valkenburg, Network Analysis, Prentice Hall of India, third edition

3. C.L.Wadhwa, Network Analysis and Synthesis, New Age International Publisher, Third

Edition.

**Theory Examination:**

1. Question paper will comprise of 6 questions, each carrying 20 marks.

2. Total four questions need to be solved.

3: Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be

asked.

4: Remaining question will be randomly selected from all the modules.

## Electronic Circuit Analysis and Design

(ECAD)

1. Diodes Circuits:

Basics of PN junction diode – Equation, characteristics.

Clipper and Clamper Circuits using diodes, Zener Diode – Characteristics and Working,

Study Zener as a voltage regulator

05

2. Bipolar Junction Transistor:

Working of PNP and NPN Transistor. Configurations (CB, CC, CE), comparison, Q-Point,

DC load line. BJT Biasing – DC analysis, Stability. (Fixed, Self, Voltage divider, Collector

to base, Collector to base self). BJT as a switch.

10

3. .A.C. Equivalent Model – re model, h-parameter model (Exact and Approximate),

Hybrid-? model

A.C. Analysis-(Using any one model): A.C. load line, A.C. analysis of CE, CB, CC

amplifier configurations, Effects of RS and RL, Comparison between various amplifiers.

Low frequency and High frequency analysis, Frequency response of Single stage

amplifier. Design of single stage amplifier using BJT.

10

4. Junction Field Effect Transistor:

Working and basic terminology related to JFET. Configurations (CS, CG, CD),

comparison, Q-Point, DC load line. JFET Biasing – Fixed, Self, Voltage divider, Concept

of stability against device parameters and temperature, zero temperature drift. A.C.

Equivalent model of JFET.

A.C. Analysis of amplifiers using CS, CG and CD amplifier configurations, Effects of RS

and RL, Comparison between various amplifiers.

Low frequency and High frequency analysis, Frequency response of Single stage

amplifier. Design of single stage amplifier using JFET.

12

5. MOSFET:

Working of Depletion and Enhancement type MOSFET Construction, Characteristics and

equations, Basic MOSFET Applications

04

6. Multistage Amplifiers:

Cascade: BJT-BJT, FET-BJT.

Cascode – DC and AC analysis, characteristics

Darlington amplifier- DC and AC analysis, characteristics

**Assessment:**

Internal Assessment consists of two tests out of which; one should be compulsory class test (on

minimum 02 Modules) and the other is either a class test or assignment on live problems or course

project.

**Books Recommended:**

Text Books:

1. Neamen Donald A., Electronics Ckt. Analyzer & Design, 2nd ed., Tata McGraw Hill.

2. Boylestad Robert L., Nashelsky Louis, Electronics Devices & Circuits, Pearson Education.

3. Semiconductor Data Manual, BPB Publications.

Reference Books:

1.Malvino—Electronic Principles , 6/e ,TMH

2. Millman & Halkias: Basic Electronic Principles; TMH.

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University of Mumbai, Biomedical Engineering, Rev 2016-17

3..Martin Roden, Gordon carpenter, William Wieseman, Electronic design, Fourth edtion,

Sroff publishers.

4. Donald Schilling & Charles Belove, Electronic Circuits Discrete and Integrated, Third

edition, Mcgraw Hill.

Theory Examination:

1. Question paper will comprise of 6 questions, each carrying 20 marks.

2. Total four questions need to be solved.

3: Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be

asked.

4: Remaining question will be randomly selected from all the modules.

## Biomaterials Prosthetics and Orthotics

(BPO)

1 Introduction: Introduction of Biomaterials, Classification

of Biomaterials, General Applications.

Techniques for characterization of Surface properties of Biomaterials: Electron

Spectroscopy for Chemical Analysis (ESCA), Secondary Ion Mass

Spectrometry(SIMS), Infrared Spectroscopy, Contact Angle Method.

08

2 Properties and Applications of Polymeric and degradable Biomaterials:

Classification, polyurethanes, PTFE, Polyethylene, Polypropylene, Polyacrylates,

PMMA, PHEMA, Hydrogel, Silicone rubber, Biopolymer in fabrication of biodevices

and implants, Thermoplastic and thermosetting plastics.

Degradable biomaterials ( PGA and PLA), applications in

drug delivery systems.

Composite Biomaterials: Properties, classification

and Applications of Composite Biomaterials in fabrication

of biodevices and implants.

Applications of biomaterials in Drug delivery systems,

09

3 Properties and Applications of Metallic Biomaterials and its Biocompatibility:

Stainless steel, Titanium, Titanium based alloys, Cobalt – Chromium alloys in

fabrication of bio-devices and implants.

Properties and Applications of Ceramic Biomaterials: Classification, Alumina,

Zirconia and types, Bioglass, Calcium Phosphate, Tricalcium phosphate in fabrication of

biodevices and implants.

08

4 Biological Testing of Biomaterials: Physiochemical Test, Mechanical Test, Invitro and

Invivo types, Different forms of corrosion, Wear, Electrochemical Corrosion Testing.

08

5 Movement biomechanics

Overview of joints and movments, anatomical levers, gait cycle ( stance and swing

phase with stick diagram), gait parameters

05

6 Prosthetics and Orthotics

Principles of three point pressure,

Lower limb prostheses, partial weight bearing-PTB socket, total contact- quadrilateral

socket.

Upper limb prosthesis ( terminal devices)

Spinal orthoses.

**Assessment:**

Internal Assessment consists of two tests out of which; one should be compulsory class test (on

minimum 02 Modules) and the other is either a class test or assignment on live problems or course

project.

**Books Recommended:**

** Text Books:**

1. Biomaterial Science and Engineering: J.V. Park (Plenum Press- New York)

2. Fundaments of Biomedical Engineering: G S. Sawhney (New Age International Publication)

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3. Biomaterial Science: An Introduction to Materials in Medicine, Ratner & Hoffmann

4. American Atlas of Orthopedics: Prosthetics, C. V. Mosby.

5. American Atlas of Orthopedics: Orthotics, C. V. Mosby

6. Basics of Biomechanics by Ajay Bahl, Jaypee publications.

Reference Books:

1. Encyclopedia of Medical Devices and Instrumentation: John G. Webster. Vol. I, II, III, IV (Marcel

Dekkar Pub).

2. Encyclopedia – Handbook of Biomaterials and Bioengineering: Part-A: Materials Vol I, II (Marcel

Dekkar Pub) Part – B: Applications Vol. I, II.

3. Design Engineering on Biomaterials for medical devices: David Hill, John Willey Publication

4. Biological Performance of Materials, 2nd Edition – Jonathan Black, Marcel Dekker Inc. New York.

Basel. Hong Kong

Theory Examination:

1. Question paper will comprise of 6 questions, each carrying 20 marks.

2. Total four questions need to be solved.

3. Q.1 will be compulsory, based on entire syllabus wherein sub questions of 2 to 5 marks will be

asked.

4. Remaining question will be randomly selected from all the modules.

## Object Oriented Programming

1 Introduction to Object

Oriented Programming

1.1OO Concepts: Object, Class, Encapsulation, Abstraction,

Inheritance, Polymorphism.

1.2Features of Java, JVM

1.3 Basic Constructs/Notions: Constants, variables and data

types, Operators and Expressions,Revision of Branching

and looping

02

2 Classes, Object

and Packages

2.1Class,Object, Method.

2.2 Constructor, Static members and methods

2.3 Passing and returning Objects

2.4Method Overloading

2.5 Packages in java, creating user defined packages, access

specifiers.

05

3 Array, String

and Vector

3.1 Arrays, Strings, StringBuffer

3.2 Wrapper classes, Vector

04

4 Inheritance

and Interface

4.1Types of Inheritance, super keyword, Method Overriding,

abstract class and abstract method, final keyword,

4.2 Implementing interfaces, extending interfaces

03

5 Exception

Handling and

Multithreadin

g

5.1 Error vs Exception, try, catch, finally, throw, throws,

creating own exception

5.2 Thread lifecycle, Thread class methods, creatingthreads,

Synchronization

04

6 GUI

programming

in JAVA

6.1 Applet: Applet life cycle, Creating applets, Graphics class

methods, Font and Color class, parameter passing.

6.2 Event Handling: Event classes and event listener

6.3 Introduction to AWT: Working with windows, Using

AWT controls- push Buttons, Label, Text Fields, Text

Area, Check Box, and Radio Buttons.

06

Note: #Out of four hours of practical two hours to be conducted as theory

**List of Laboratory Experiments: (Any Fifteen experiments and three assignments)**

1. Program on various ways to accept data through keyboard and unsigned right shift operator.

2. Program on branching, looping, labelled break and labelled continue.

3. Program to create class with members and methods, accept and display details for single object.

4. Program on constructor and constructor overloading

5. Program on method overloading

6. Program on passing object as argument and returning object

7. Program on creating user defined package

University of Mumbai, Biomedical Engineering, Rev 2016-17

8. Program on 1D array

9. Program on 2D array

10. Program on String

11. Program on StringBuffer

12. Program on Vector

13. Program on single and multilevel inheritance (Use super keyword)

14. Program on abstract class

15. Program on interface demonstrating concept of multiple inheritance

16. Program on dynamic method dispatch using base class and interface reference.

17. Program to demonstrate try, catch, throw, throws and finally.

18. Program to demonstrate user defined exception

19. Program on multithreading

20. Program on concept of synchronization

21. Program on Applet to demonstrate Graphics, Font and Color class.

22. Program on passing parameters to applets

23. Program to create GUI application without event handling using AWT controls

24. Program to create GUI application with event handling using AWT controls

Assessment:

**Term Work:**

Term work shall consist of minimum 15 experiments and 3 **Assignments**

The distribution of marks for term work shall be as follows:

Laboratory work (Experiments): 20 Marks

Laboratory work (journal) : 10 Marks

Assignments : 15 Marks

Attendance : 5 Marks

The final certification and acceptance of term work ensures the satisfactory performance of laboratory

work and minimum passing in the term work.

**Books Recommended:**

Text books:

1. Herbert Schildt, ‘JAVA: The Complete Reference’, Ninth Edition, Oracle Press.

2. Sachin Malhotra and Saurabh Chaudhary, “Programming in Java”, Oxford University

Reference Books:

1. Ivor Horton, ‘Beginning JAVA’, Wiley India.

2. DietalandDietal, ‘Java: How to Program’, 8/e,PHI

3. ‘JAVA Programming’, Black Book, Dreamtech Press.

Practical and oral examination will be based on suggested practical list and entire syllabus.

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Course

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